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The science behind erectile dysfunction treatment is complex and multifaceted. Tadalafil (Cialis, Adcirca, and others) works by increasing blood flow to the penis, allowing for an erection to occur. This is achieved through the inhibition of phosphodiesterase type 5 (PDE5), an enzyme that breaks down cyclic guanosine monophosphate (cGMP). cGMP is a molecule that relaxes smooth muscle and increases blood flow, allowing for an erection to occur.
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